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Lanjing Zhang, MD
Department of
Chemical Biology Rutgers University Piscataway, NJ 08854 |
Machine learning, Cancer, Epidemiology
Full Member Rutgers Cancer
Institute of New Jersey Fax: (732) 445-0687
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Current Research
1. IIS-2128307
EAGER: Integration and analysis of high-dimensional dataset
Selected publications
1.
Chavali LB# Hu K#, Sheth A, Gao N, Xiong W*, Zhang
L* (2020) Clinicopathological characteristics and synchronous neoplasm of
sessile serrated adenoma. Eur J Gastroenterol Hepatol. 32(2):199-204. DOI: 10.1097/MEG.0000000000001642 PMID: 31851088
2.
Zhang M, Hu
W, Hu K, Lin Y, Feng Z, Yun JP, Gao N, Zhang L. (2020) Association of Kras mutation with tumor deposit status and overall
survival of colorectal cancer. Cancer Causes Control. 31(7):683-689. DOI: 10.1007/s10552-020-01313-0 PMID: 32394229
3.
Yu S,
Balasubramanian I, Laubitz D, Tong K, Bandyopadhyay
S, Lin X, Flores J, Singh R, Liu Y, Macazana C, Zhao
Y, B guet-Crespel F, Patil K, Midura-Kiela
MT, Wang D, Yap GS, Ferraris RP, Wei Z, Bonder EM, H ggblom
MM, Zhang L, Douard V, Verzi
MP, Cadwell K, Kiela PR,
Gao N. (2020) Paneth Cell-Derived Lysozyme Defines the Composition of
Mucolytic Microbiota and the Inflammatory Tone of the Intestine. Immunity.
53(2):398-416.e8. PIMD: 32814028
4.
Deng F, Zhou
H, Lin Y, Heim J, Shen L, Li Y, Zhang L. (2021) Predict multicategory causes
of death in lung cancer patients using clinicopathologic factors. Comput Biol Med 129:104161 Doi: 10.1016/j.compbiomed.2020.104161 PMID: 33307409
5.
Deng F,
Huang J, Yuan X, Cheng C, Zhang L. (2021) Performance and efficiency of
machine learning algorithms for analyzing rectangular biomedical data. Lab
Invest. 101(4):430-441. doi: 10.1038/s41374-020-00525-x. PMID: 33574440.
6.
Zhang B, Yao
K, Zhou E, Zhang L, Cheng, C. (2021) Chr20q amplification defines a distinct
molecular subtype of microsatellite stable colorectal cancers. Cancer Res.
15;81(8):1977-1987. PMID: 33619118
7.
Chang CY,
Wang J, Zhao Y, Liu Y, Yang X, Yue X, Wang H, Zhou F, Inclan-Rico
J, Ponessa J, Xie P, Zhang
L, Siracusa M, Feng Z, Hu W. (2021) Tumor
suppressor p53 regulates intestinal type 2 immunity. Nat Commun. 12(1):3371. PMID: 34099671.
8.
Feng CH, Disis ML, Cheng C, Zhang L. (2021) Multimetric feature selection for analyzing multicategory
outcomes of colorectal cancer: random forest and multinomial logistic
regression models. Lab Invest. doi: doi: 10.1038/s41374-021-00662-x. PMID: 34537824
9.
Shen M, Wei
Y, Kim H, Wan L, Jiang YZ, Hang X, Raba M, Remiszewski
S, Rowicki M, Wu CG, Wu S, Zhang L, Lu X, Yuan M,
Smith HA, Zheng A, Bertino J, Jin
JF, Xing Y, Shao ZM, Kang Y. (2022) Small-molecule inhibitors that disrupt the
MTDH SND1 complex suppress breast cancer progression and metastasis. Nat
Cancer. 3(1):43-59. PMID: 35121987
10. Cui M, Cheng C*, Zhang L*. (2022) High-throughput
proteomics: a methodological mini-review. Lab Invest. 102(11):1170-1181. doi: 10.1038/s41374-022-00830-7.
PMID: 35922478
11. Liu J, Zhang C, Zhang T, Chang CY, Wang J,
Bazile L, Zhang L, Haffty BG, Hu W, Feng Z. (2022) Metabolic
enzyme LDHA activates Rac1 GTPase as a noncanonical mechanism to promote cancer.
Nat Metab. 4(12):1830-1846. doi:
10.1038/s42255-022-00708-4. PMID: 36536137.
12. Liu J, Zhang C, Xu D, Zhang T, Chang CY, Wang
J, Liu J, Zhang L, Haffty BG, Zong
WX, Hu W, Feng Z. (2023) The ubiquitin ligase TRIM21 regulates mutant p53
accumulation and gain-of-function in cancer. J Clin Invest. 2023 Feb
7:e164354. doi: 10.1172/JCI164354. Epub ahead of print. PMID: 36749630.
13. Deng F, Zhao L, Yu N, Lin Y, Zhang L. Union
With Recursive Feature Elimination: A Feature Selection Framework to Improve
the Classification Performance of Multicategory Causes of Death in Colorectal
Cancer. Lab Invest. 2023 Dec 28;104(3):100320. doi:
10.1016/j.labinv.2023.100320. PMID: 38158124.
14. Yang L, Peery RC, Farmer LM, Gao X, Zhang Y,
Creighton CJ, Zhang L, Shen L. Dietary Folate and Cofactors Accelerate
Age-dependent p16 Epimutation to Promote Intestinal Tumorigenesis. Cancer
Res Commun. 2024 Jan 19;4(1):164-169. doi: 10.1158/2767-9764.CRC-23-0356. PMID: 38259096
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